Alice: Madness Returns is set over a decade after the original game.

Alice is finally free from the Rutledge Insane Asylum, and is placed into the care of a psychiatrist who will try to help her conquer her nightmarish hallucinations. Alice is still struggling to recover from the emotional trauma of the fatal fire that accidentally killed her family. The repressed memories start to come back to her, but the stress caused by regaining these lost memories cause her hallucinations and internal struggle to increase in severity.

Alice embarks on an adventure to try to retain her sanity by seeking out the truth of her families’ mysterious accidental death and to save the residents of Wonderland from the evil that is trying to take over. Cross worlds between a gloomy London setting to a richly provocative Wonderland.